Fabrication of bimodal porous PLGA scaffolds by supercritical CO2foaming/particle leaching technique

Specific pore structure is a vital essential for scaffolds applied in tissue engineering. In this article, poly(lactide-co-glycolide) (PLGA) scaffolds with a bimodal pore structure including macropores and micropores to facilitate nutrient transfer and cell adhesion were fabricated by combining supercritical CO2 (scCO2) foaming with particle leaching technique. Three kinds of NaCl particles with different scales (i.e., 100–250