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A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions
- Source :
- Green Chem.. 16:4922-4930
- Publication Year :
- 2014
- Publisher :
- Royal Society of Chemistry (RSC), 2014.
-
Abstract
- A convenient solvent-free method for the synthesis of benzothiazole, benzimidazole, and benzoxazole derivatives has been developed using recyclable ZnO-NPs via a ball-milling strategy. The method affords environmentally friendly reaction conditions that score high on the ecoscale with the low E-factor. The process is also highly efficient even on a multi-gram scale and provides easy product isolation.
Details
- ISSN :
- 14639270 and 14639262
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Green Chem.
- Accession number :
- edsair.doi...........d5f4424eb2afe6bacbeadb96d08aa847