ChemInform Abstract: Reaction of N,N-Disubstituted α-Aminomethyleneketones with Tosylisocyanate. Synthesis of Amino-disubstituted 2-Acyl-3-amino-N-tosylpropenamides, N,N-(3-Amino-1-alkyl-2-propenylidene) and N,N-[2-(Aminomethylene)cyclohexylidene]tosylami

The reaction of N,N-disubstituted open-chain and cyclohexane alpha-aminomethyleneketones (I) and (II) with p-toluenesulfonyl (tosyl) isocyanate gave amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides (III) and/or N,N-(3-amino-1-alkyl-2-propenylidene) and N,N-[2-(aminomethylene)-cyclohexylidene] tosylamides (IV) and (V), the final product being related to the carbon and nitrogen substituents of the enaminone. The evaluation of the hypoglycemic activity concerning some of the above compounds gave no interesting results.