Association between serum uric acid, high sensitive C-reactive protein and pro-oxidant-antioxidant balance in patients with metabolic syndrome

Background and aims: There is persuasive evidence that oxidative stress and inflammation are features of the metabolic syndrome (MetS). We have investigated the relationship between serum pro-oxidant antioxidant balance (PAB), serum uric acid and high sensitive C-reactive protein (hs-CRP) in 7208 participants from the MASHAD study cohort, who were categorized as having MetS, or not, using IDF criteria. Methods: Serum fasting lipid, fasting blood glucose and uric acid concentrations were measured enzymatically using commercial kits on a BT- 3000 autoanalyzer (Biotechnical, Rome, Italy). Serum hs-CRP was measured by PEG-enhanced immunoturbidimetry method using an Alycon analyzer (ABBOTT, Chicago, IL, USA). A colorimetric method was used to determine serum PAB. Results: Serum PAB values were significantly higher in the individuals with MetS compared to those without MetS (p