ChemInform Abstract: Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-Oxazinanes, and 1,3-Oxazinan-2-ones Starting from 4-Trifluoromethyl-β-lactam Building Blocks

This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, and 1,3-oxazinan-2-ones. This β-lactam building block approach provides a convenient new entry into trifluoromethylated scaffolds as useful synthetic intermediates en route to a variety of CF3-functionalized target structures.