THE EFFECT OF KELP ON SERUM LIPIDS OF HYPERLIPIDEMIA IN RATS

Hyperlipidemia is one kind of common and frequently occurring syndromes and closely related to cardiovascular and cerebrovascular disease occurrences in the world. It is significant to explore the marine foods and potential drug resources for the application in treating the hyperlipidemia. We conducted this study to investigate the reducing effect and mechanism of kelp (Saccharina japonica) on serum lipid of rat models with hyperlipidemia induced by a fat-rich diet. The levels of serum lipid including the triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were detected by biochemical assay. Enzyme-linked immunosorbent assay was applied to determine the level of oxidized LDL (ox-LDL). The activity of lipoprotein lipase (LPL) and hepatic lipase (HL) was determined by chemical colorimetry. The concentrations of malondialdehyde (MDA) and nitric oxide (NO) were respectively measured by thiobarbituric acid assay and nitrate reductase assay. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were respectively determined by xanthinoxidase assay and chemical colorimetry. The results showed that the serum levels of TG, TC and LDL decreased, while HDL increased significantly in treated group compared with those of model groups (P