Frequency of non-polypotic familiar colon cancer in Uruguayan patients with colorectal cancer

3730 Background: Non-polypotic familiar colon cancer (HNPCC) is an autosomical dominant transmitted syndrome with high aggregation of colorectal cancer (CRC), frequently associated with other solid tumors. Few studies have investigated the frequency of HNPCC in patients (pts.) having undergone surgery for CRC. These have shown a marked geographic variation, ranging from 0.5% to 13%. The aim of this study is to estimate the frequency of HNPCC in the Uruguayan population. Methods: We performed a retrospective analysis of a cohort of non-selected pts. operated for CRC in the Hospital Central de las Fuerzas Armadas (Montevideo, Uruguay) between January 1987 and December 2002. Cases were classified in 3 groups according to personal and family history: 1) those fulfilling Amsterdam criteria, classified as HNPCC; 2) those not fulfilling Amsterdam criteria but considered as a population of increased risk for cancer (PIR); and 3) those classified as sporadic CRC. Genetic analysis to detect mutations in hMLH1 and h...