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Evaluation of thrombogenic potential by partial differential equations in the blood flow dynamics with central venous catheter
- Source :
- Journal of the Brazilian Society of Mechanical Sciences and Engineering. 41
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- This paper presents for the first time a numerical prediction of the thrombogenic potential by means of partial differential equation in computational fluid dynamics for cardiovascular devices. To quantify the thrombogenic potential was developed the Platelet Lysis Index equation in an Eulerian model. Six different catheter tip models with the results obtained from the literature, however, with Lagrangian approach were compared. Three-dimensional computational fluid dynamics was done with a realistic central venous catheter model. The partial differential equation covers the entire computational domain, allowing the visualization of the regions with the highest platelet activation. In the realistic catheter, the first arterial proximal hole was the region with the highest Platelet Lysis Index and shear rate. Despite all limitations and considerations, the use of the Eulerian model allows a quick numerical comparison of the thrombogenic potential of cardiovascular device, being a useful tool in its design.
- Subjects :
- 0209 industrial biotechnology
Partial differential equation
business.industry
Computer science
Mechanical Engineering
Applied Mathematics
medicine.medical_treatment
Dynamics (mechanics)
General Engineering
Aerospace Engineering
02 engineering and technology
Mechanics
Blood flow
Computational fluid dynamics
Industrial and Manufacturing Engineering
Domain (mathematical analysis)
Catheter
020901 industrial engineering & automation
Automotive Engineering
medicine
Platelet activation
business
Central venous catheter
Subjects
Details
- ISSN :
- 18063691 and 16785878
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of the Brazilian Society of Mechanical Sciences and Engineering
- Accession number :
- edsair.doi...........d4819555266e184c62a7d0341fbacf97