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Metabolomic profiling and anti-infective potential of Zinnia elegans and Gazania rigens (Family Asteraceae)
- Source :
- Natural Product Research. 34:2612-2615
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- The present study evaluates the chemical composition of Zinnia elegans and Gazania rigens based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for Z. elegans, while amides and phenolic acid derivatives were characteristic for G. rigens. These results highlight the chemical potential of Z. elegans and G. rigens. Furthermore, the ethyl acetate fraction of Z. elegans showed a significant antimalarial activity with IC50 values of 21.03 and 13.72 µg/mL against Plasmodium falciparum D6 and P. falciparum W2, respectively.
- Subjects :
- biology
010405 organic chemistry
Organic Chemistry
Gazania rigens
Ethyl acetate
Zinnia elegans
Plasmodium falciparum
Plant Science
Phenolic acid
biology.organism_classification
Sesquiterpene
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Metabolomics
chemistry
Liquid chromatography–mass spectrometry
Botany
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi...........d4483c8462431c612b1376b0c95ed825