Advances in Transition-Metal-Catalyzed Direct sp3-Carbon–Hydrogen Bond Functionalization

Transition-metal-catalyzed direct carbon–hydrogen bond functionalization has made significant advances in the field of carbon–hydrogen bond activation over the past decades. This methodology has the potential to be used in many different areas of chemistry; for example, it can provide an opportunity for the synthesis of various kinds of complex compounds. This account mainly focuses on recent advances in transition-metal-catalyzed direct sp3-carbon–hydrogen bond functionalization to form carbon–carbon bonds. 1 Introduction 2 Carbon–Carbon Bond Formation via Direct sp3-Carbon–Hydrogen Bond Functionalization 2.1 Coupling of sp3-Carbon–Hydrogen and sp-Carbon–Hydrogen Bonds 2.2 Coupling of sp3-Carbon–Hydrogen and sp2-Carbon–Hydrogen Bonds 2.3 Coupling of sp3-Carbon–Hydrogen and sp3-Carbon–Hydrogen Bonds 2.4 Coupling of sp3-Carbon–Hydrogen and C–X Bonds 3 Conclusion