Automatic image guidance for prostate IMRT using low dose CBCT

Purpose: Varian’s On-Board Imager is a linac-integrated cone-beam CT(CBCT) system used at the authors’ institution to acquire images prior to delivering each fraction of prostate intensity modulated radiotherapy. The images are used to determine a couch shift that realigns the tumor with the position obtained in the planning CT. However, this manual image-guided radiotherapy (IGRT) technique is operator dependent, time consuming, offers limited degrees of freedom, and requires significant imagingdose over the course of treatment. To overcome these problems, the authors propose two fully automatic IGRT techniques that require significantly less imagingdose. Methods: Dose is reduced by lowering the x-ray tube mA s during CBCT acquisition at the cost of increasing imagenoise. In “forward” IGRT, the CBCTimage is automatically registered to the planning CT to obtain the necessary couch shift. The “reverse” technique offers additional degrees of freedom as it involves nonrigid registration of the planning CT to the CBCT. Both techniques were evaluated using images of an anthropomorphic phantom with simulated motion and by retrospectively analyzing data from ten prostate cancer patients. Results: IGRT error for the phantom data at 100% relative imagingdose was 8.2 ± 3.7 , 3.5 ± 1.2 , and 2.1 ± 0.6 mm for setup only, forward, and reverse techniques, respectively. For patient images acquired at 100% relative imagingdose, the errors were 5.4 ± 1.7 , 5.0 ± 1.6 , 5.0 ± 2.0 , and 4.0 ± 1.6 mm for setup only, manual forward (performed clinically), automatic forward, and reverse IGRT, respectively. Furthermore, imagingdose could be reduced to 20% without a significant loss in image guidance accuracy. Conclusions: The presented image guidance methods are accurate while requiring only 20% of the standard imagingdose. The combination of low dose, automation, and accuracy enables frequent corrections during treatment, possibly leading to reduced margins and improved treatment outcomes.