Influence of the Environmental Isotope Composition Modification on Growth and Metabolic Activity of Rhodococcus and Saccharomyces

The level of CO2 production and the growth dynamics of the biomass of Rhodococcus erythropolis VKM Ac2017D (Russia) and the yeast strain Saccharomyces cerevisiae OenofermC2 (France) were determined in cultivation media with variously reduced (from 10 to 150 ppm) deuterium concentration. The maximum increase in the rhodococcal biomass was shown in the media with a deuterium concentration of 50 ppm or less. It was noted that the production of CO2 as an integral indicator of the biological activity of cells is more pronounced in Rhodococcus compared to the yeast. With generally similar dynamics of CO2 emission curves, prokaryotes showed broader temporal dynamics of its production.