Cardiometabolic Follow Up of the Offspring From the Metformin in Obese Non-Diabetic Pregnant (MOP) Women Trial

Background: Maternal obesity is associated with adverse cardiometabolic outcome in the offspring. We aimed to assess whether prenatal exposure to metformin can improve the cardiovascular profile and body composition in the offspring of obese mothers. Methods: In 151 children from the MOP trial we measured body composition, peripheral blood pressure and arterial pulse wave velocity. Central haemodynamics (central blood pressure and augmentation index) were estimated using the Vicorder device. Left ventricular cardiac function and structure were assessed by echocardiography. In 39 children from each group the metabolic profile was assessed. Findings: Children were 3.9±1.0 years of age and 77 were exposed to metformin prenatally. There was no significant difference in peripheral blood pressure, arterial stiffness and body composition apart from gluteal and tricep circumferences which were lower in the metformin group (p