P029 Oral iron supplementation promotes inflammation and colorectal carcinogenesis in a mouse model of colitis-associated cancer

findings. Endoscopic activity was classified as active and quiescent disease, based on the endoscopic Mayo Subscore (UC) and SES-CD (CD) index. In cases with active disease, biopsies were taken from both endoscopically affected and non-affected mucosa. Following pathologist’s criteria, biopsies were classified as normal, affected mucosa, unspecific inflammation, and quiescent. Results: 67 biopsies from 52 patients with histological diagnosis of IBD (31 UC and 21 EC) and 19 from subjects without IBD were studied. 38.6% cases had active disease. MV count was lower in samples from patients without IBD (Table 1; p < 0.0001), even when comparing only normal mucosa. Patients with UC showed the highest count of Ang1+MV in both cases (Table 2). MV density was also increased in samples with endoscopic activity (52.3±19.5 vs 41.7±15.8; P= 0.02) but it did not correlate with histology.