The effect of CP-96,345, a non-peptide substance-P antagonist, on thermoregulation and the development of endotoxin-fever in rats

1. Substance-P (SP) has been shown to induce a regulated rise in body temperature when injected into one of the lateral cerebral ventricles of rats. 2. The non-peptide antagonist of SP (CP-96,345) decreased the SP-induced rise in core temperature and, when given prior to an intravenous endotoxin injection, it also attenuated the febrile response to endotoxin.