ChemInform Abstract: Catalytic Asymmetric Addition Reaction of Dialkylzinc to Nitrone Utilizing Tartaric Acid Ester as a Chiral Auxiliary

The catalytic asymmetric addition reaction of dialkylzinc to carbon-nitrogen double bond in 3,4-dihydroisoquinoline N-oxide derivatives was achieved by utilizing a catalytic amount of dicyclopentyl (R,R)-tartrate to afford the corresponding (S)-hydroxylamines in high optical yields up to 94% ee.