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Diversity and Antifungal Drug Susceptibility ofCryptococcusIsolates in Thailand: Table 1
- Source :
- Medical Mycology. :myw130
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Yeasts of the Cryptococcus species complex are the causative agent of cryptococcosis, especially in human immunodeficiency virus (HIV) positive individuals. Cerebral or disseminated cryptococcosis has a very high mortality rate worldwide, including in Thailand. Additionally, an increasing rate of antifungal drug resistant cryptococcal isolates has been reported in several neighboring countries, complicating therapeutic approaches. To understand the situation of this infection in Thailand, we retrospectively investigated the molecular epidemiology and antifungal drug resistance in a collection of 74 clinical, 52 environmental and two veterinary isolates using the URA5-RFLP for typing and the EUCAST guideline for susceptibility testing. Where no EUCAST breakpoints (AMB and 5FC) were available, CLSI epidemiologic cutoff values were used for interpretation. Cryptococcal molecular type diversity showed most isolates were C. grubii, molecular type VNI. One clinical isolate was C. deuterogattii (mol. type VGII) and another C. grubii (mol. type VNII). One strain from environment was classified as C. grubii (mol. type VNII). No resistant strains were detected in this retrospective study for either of the antimycotics tested; however, monitoring of the epidemiology of Cryptococcus species in infected patients in Thailand needs to be continued to detect emergence of resistance.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
biology
Molecular epidemiology
Mortality rate
030106 microbiology
Cryptococcus
Antifungal drug
General Medicine
biology.organism_classification
medicine.disease
Virology
3. Good health
Microbiology
03 medical and health sciences
Infectious Diseases
Disseminated cryptococcosis
Cryptococcosis
Epidemiology
medicine
Typing
Subjects
Details
- ISSN :
- 14602709 and 13693786
- Database :
- OpenAIRE
- Journal :
- Medical Mycology
- Accession number :
- edsair.doi...........d204f568a027007fa7db717c7e213ced