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Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop
- Source :
- Catalysis Today. :231-236
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- We describe a novel strategy to increase the unit-time-productivity of flow synthesis by using hierarchical bimodal porous silica gel (HBPSG) supported palladium column reactors. Because HBPSG has a significantly large surface area, the column reactors have low pressure drop, enabling high-volume production. We demonstrated flow synthesis of the precursor of adapalene, a pharmaceutical compound, at 5 g/h which is over 10-fold greater productivity than previous approaches.
- Subjects :
- Pressure drop
Materials science
Silica gel
Flow (psychology)
chemistry.chemical_element
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Chemical engineering
0210 nano-technology
Porosity
Column (data store)
Palladium
Subjects
Details
- ISSN :
- 09205861
- Database :
- OpenAIRE
- Journal :
- Catalysis Today
- Accession number :
- edsair.doi...........d16636fb3961bf3dfc84bf486d1b1208