Controlling Hypertension after Severe Cerebrovascular Event (CHASE): A Randomised, Multicentre, Controlled Study

Background: The optimal BP-lowering target in the acute phase of severe stroke is uncertain. We aimed to compare the efficacy and safety of individualised BP lowering with standard BP lowering in severe stroke. Methods: We conducted a randomised, multicentre study in 26 hospitals in China. Eligible patients were randomised into an individualised BP-lowering group (with 10-15% reduction in systolic BP [SBP] from admission level) or standard BP-lowering group (with a target SBP of