Synthesis of Spherical Phosphorus-Containing Mesoporous Silica for Improving their Reaction Behavior in Simulated Body Fluid

Spherical phosphorus–containing mesoporous silica (PMPS) particles were synthesized. In the PMPS particle preparation using the cationic surfactant (cetyltrimethylammonium bromide) as the template, the amphiphilic surfactant (Pluronic P123) and diethyl(2–bromoethyl)phosphonate were used for the particle shape control and the phosphorus source, respectively. Furthermore, we investigated the chemical reactions of the PMPS particles in simulated body fluid (SBF). By the phosphorus–containing, the hydroxyapatite formation and silicate ion dissolution ability on the PMPS particle surfaces were enhanced. These characteristic features will be useful for the biomedical applications such as bone formation.