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Iron‐Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp 3 )–H Amination
- Source :
- Angewandte Chemie International Edition. 60:8772-8780
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3 )-H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.
- Subjects :
- Natural product
010405 organic chemistry
Drug discovery
Homogeneous catalysis
General Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Mechanism (philosophy)
Molecule
Rearrangement reaction
Amination
Subjects
Details
- ISSN :
- 15213773 and 14337851
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi...........d0b20f4431acf1050205e4b8f7251ee1