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Role of ABCA1 in Cardiovascular Disease

Authors :
Jing Wang
Qianqian Xiao
Luyun Wang
Yan Wang
Daowen Wang
Hu Ding
Source :
Journal of Personalized Medicine. 12:1010
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon binding with apolipoprotein A-I, ABCA1 facilitates the efflux of excess intracellular cholesterol and phospholipids and controls the rate-limiting step of reverse cholesterol transport. In addition, ABCA1 interacts with the apolipoprotein receptor and suppresses inflammation through a series of signaling pathways. Thus, ABCA1 may prevent cardiovascular disease by inhibiting inflammation and maintaining lipid homeostasis. Several studies have indicated that post-transcriptional modifications play a critical role in the regulation of ABCA1 transportation and plasma membrane localization, which affects its biological function. Meanwhile, carriers of the loss-of-function ABCA1 gene are often accompanied by decreased expression of ABCA1 and an increased risk of cardiovascular diseases. We summarized the ABCA1 transcription regulation mechanism, mutations, post-translational modifications, and their roles in the development of dyslipidemia, atherosclerosis, ischemia/reperfusion, myocardial infarction, and coronary heart disease.

Subjects

Subjects :
Medicine (miscellaneous)

Details

ISSN :
20754426
Volume :
12
Database :
OpenAIRE
Journal :
Journal of Personalized Medicine
Accession number :
edsair.doi...........d0297716280d816fc03e1c6b8ab1490e