ChemInform Abstract: Discovery and SAR of Org 24598 - A Selective Glycine Uptake Inhibitor

Authors :: Angus R. Brown
William Hamilton
Rae Duncan Robertson
Samuel George Gibson
George McGarry
John K. Clark
Glenn Walker
Simon Nicholas Thorn
Ian Craig Carlyle
Sandra McEachen
Source :: ChemInform. 32
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed.

Subjects :: Glycine transporter
Chemistry
Stereochemistry
Glycine
General Medicine
Ligand (biochemistry)
In vitro

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