Latticed Channel Model of Touchable Communication over Capillary Microcirculation Network

Recent progress on bioresorbable and biocompatible miniature systems provides prospects for developing novel nanobots operating inside the human body. These nanoscale systems are expected to dissolve in vivo and cause no side effect after completing their tasks. Motivated by these advancements, we have developed the analytical framework of touchable communication (TouchCom) to describe the process of targeted drug delivery (TDD) using physically transient nanobots. Built upon our previous work, we develop a novel latticed channel model of TouchCom for an interconnected capillary network near a targeted tumor area. Specifically, we propose a two-dimensional grid to synthesize the microcirculation environment, which is used to describe the propagation process of nanobots. Based on this model, we consider the influence of blood pressure on the efficiency of TDD, and introduce a compensation strategy with the help of an external guiding field to mitigate the misalignment between the direction of blood pressure and the tumor location.