The Divergent Transformations of Aromatico-Aminonitrile with Carbonyl Compound

Authors :: Xiuzhen Wang
Shuling Ma
Change Liu
Liu-Pan Yang
Daxin Shi
Qi Zhang
Lijun Zhang
Jianhong Tang
Xuan Liu
Jiarong Li
Source :: Journal of Heterocyclic Chemistry. 49:533-542
Publication Year :: 2012
Publisher :: Wiley, 2012.
Abstract: A modified Friedlander conversion of the cyclocondensation of aromatic o-aminonitriles with carbonyl compounds was discovered. Systematic studies reveal that both the new transformation and the classic Friedlander annulation in the presence of ZnCl2 constitute a pair of divergent reaction, and thecontrolled PDF transformation of this divergent reaction was achieved in the present of bases.