A15830 Potential Reversal of Upregulated Renin-Angiotensin System by Endothelin Antagonism in the hypertrophied Heart of Stroke Prone Spontaneously Hypertensive Rat (SHR-SP)

Authors :: Md. Arifur Rahman
Nobutake Shimojo
Farzana Sohael
Ahsan Habib
Md. Majedul Islam
Sayeeda Nusrat Sultana
Osamu Okazaki
Yashio Yashima
S. Kawano
Naoto Yamaguchi
Subrina Jesmin
Hisashi Sanada
Source :: Journal of Hypertension. 36:e81
Publication Year :: 2018
Publisher :: Ovid Technologies (Wolters Kluwer Health), 2018.
Abstract: Objectives:It is unknown whether endothelin (ET)-1 affects the production of angiotensin II (AII) in the heart. We hypothesized that ET-1 may act on the upstream of renin-angiotensin system (RAS) in the hypertrophied heart. The aim was to investigate the effects of the ET blockade on the expression

Subjects :: medicine.medical_specialty
Physiology
business.industry
medicine.disease
Angiotensin II
Blockade
Endocrinology
Spontaneously hypertensive rat
Downregulation and upregulation
Internal medicine
Renin–angiotensin system
Internal Medicine
medicine
Cardiology and Cardiovascular Medicine
Endothelin receptor
business
Antagonism
Stroke

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