In vitro display evolution of unnatural peptides spontaneously cyclized via intramolecular nucleophilic aromatic substitutions

Authors :: Takumi Yokoyama
Takehiro Ando
Yukio Takamori
Daisuke Fuji
Masashi Sato
Santhana Vedi
Mizuki Yamamoto
Takashi Kawakami
Source :: Chemical Communications. 58:5237-5240
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: We report novel spontaneous peptide cyclization by intramolecular nucleophilic aromatic substitutions using ribosomally incorporatable and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers.

Subjects :: Materials Chemistry
Metals and Alloys
Ceramics and Composites
General Chemistry
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials

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