Trinucleotide Repeat Expansions: Disorders

Trinucleotide repeat mutations, also known as dynamic mutations, were discovered only in the early 1990s, but are responsible for many important neurological disorders, such as Huntington disease, fragile X mental retardation and myotonic dystrophy. Keywords: triplet repeat; dynamic mutation; polyglutamine; Huntington disease; protein aggregate; spinocerebellar ataxia