SAT0674 ADIPOKINES AND ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

Background Premature atherosclerosis is clearly described in systemic lupus erythematosus as a main cause of poor outcomes and mortality(1).Pleiotropic adipokines including adiponectin and visfatin are implicated in the inflammatory process of lupus disease that promote cytokines signaling leading accelerated endothelial disruption(2) Objectives To evaluate the endothelial dysfunction by measuring serum visfatin,adiponectin,leptin and HOMA-insulin Index as reliable biomarkers of atherosclerosis &estimating the FMD of brachial artery among lupus patients and correlating these parameters with clinical characteristics Methods A case-control study in which 150 systemic lupus patients who were fulfilling American College of Rheumatology revised classification were recruited consecutively from Internal Medicine department at Cairo University.They were compared to 90 age & sex matched healthy controls. Patients who were pregnant,smoker,diabetic,those with hepatic and renal dysfunction, hypothyroidism,and familial dyslipidemia were excluded.Adiponectin,leptin,visfatin and HOMAIR were evaluated.Flow mediated dilatation of brachial artery was calculated as the maximum percent increase in artery diameter after cuff release compared to baseline Results Data revealed elevated levels of adiponectin,leptin,visfatin and HOMAIR in lupus cases compared to controls with reduced FMD percent.Clinical and laboratory background are summarized in table(1) Table(1) None of adipokines is correlated to age,BMI,Disease duration or activity.An inverse correlation between FMD of the brachial artery and total cholesterol, visfatin, adiponectin, leptin and HOMAIR (r-value=-0.523,- 0.35,-0.27,-0.45,-0.56 respectively)with P Conclusion Endothelial dysfunction is evident in SLE.Reduced FMD of brachial artery and increased adipokines &HOMAIR are noted.Adiponectin and visfatin could be predictors of atherosclerosis in lupus References [1] Nassef S, Essam M, Abdelfattah D, et al. Evaluation of Impact of Interferon-Induced Helicase C Domain-Containing Protein 1 Gene in Egyptian Systemic Lupus Erythematosus Patients and its Relationship With Vascular Manifestations of the Disease. Arch Rheumatol 2018;33(2):181–9. [2] Li H, Zhang T, Leng R, Li X. Emerging role of adipokines in systemic lupus erythematosus. Immunol Res. 2016;64(4):820–30. Acknowledgement to all participants in this work Disclosure of Interests None declared