THE URINARY EXCRETION OF ESTROGENS, ANDROGENS AND FSH FOLLOWING THE ADMINISTRATION OF TESTOSTERONE TO HUMAN FEMALE CASTRATES

AEMLIORATION of the vaso‘motor symptoms of the menopause by the AMELIORATION use of testosterone.propionate has been reported by several investi ‘gators (1-4). Salmn (1) noted a change in the vaginal smear from the menc pausal to the cornified type, which was not found by Shorr et al. (2). Both, however, observed a decrease in the levels of FSH after treatment with testosterone became effective. It was concluded that testosterone had the same effect as the estrogens, that is, inhibition of the anterior pituitary gland. This study was undertaken to ascertain if there were changes from the pre’treatment levels of urinary FSH, androgens and estrogens, after ad‘ ministration of testosterone propionate1 to female castrates. Similar work on normal males, eunuchoids and female castrates, to be referred to later in this paper, has been reported by others during the course of these experiments. Subjects. Four women who had severe menopausal symptoms following surgical or radiation castration were selected for this...