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Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer’s disease diagnosis
- Source :
- Bio-Design and Manufacturing. 1:182-194
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles (f-PNPs) array for simultaneous multi-biomarker detection that can be used in Alzheimer’s disease (AD) diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctor’s check-up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a-chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as “the holy grail” of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.
- Subjects :
- Human blood
Process (engineering)
Computer science
Materials Science (miscellaneous)
Biomedical Engineering
02 engineering and technology
Lab-on-a-chip
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Industrial and Manufacturing Engineering
0104 chemical sciences
law.invention
Nanomanufacturing
Computer architecture
law
0210 nano-technology
Manufacturing efficiency
Biotechnology
Subjects
Details
- ISSN :
- 25228552 and 20965524
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Bio-Design and Manufacturing
- Accession number :
- edsair.doi...........ce05a3ce7758e3b66dab7cf956a3000c