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The Comparison between Free Thyroxine and Thyroid-Stimulating Hormone Levels on Melasma Severity: A Cross-Sectional Study
- Source :
- Open Access Macedonian Journal of Medical Sciences. 9:426-431
- Publication Year :
- 2021
- Publisher :
- Scientific Foundation SPIROSKI, 2021.
-
Abstract
- Background: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone level with melasma severity. Objective: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma by using two different measurement techniques. Methods: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusomo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. Results: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), P 0.375 and P 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r=0.3; P 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r= 0.314; P 0.03). Conclusion: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity.
- Subjects :
- medicine.medical_specialty
Melasma
Cross-sectional study
business.industry
Thyroid
General Medicine
Free thyroxine
medicine.disease
Positive correlation
Dermatology
Weak correlation
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Thyroid-stimulating hormone
030220 oncology & carcinogenesis
medicine
business
Hormone
Subjects
Details
- ISSN :
- 18579655
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Open Access Macedonian Journal of Medical Sciences
- Accession number :
- edsair.doi...........cda425f9a616e2be8ac03c5de8407df1