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A Water Soluble Zinc(II) Coordination Polymer Containing Pyridazine-4,5-Dicarboxylic Acid: The Crystal Structure and Binding Properties with DNA
- Source :
- Russian Journal of Coordination Chemistry. 44:317-321
- Publication Year :
- 2018
- Publisher :
- Pleiades Publishing Ltd, 2018.
-
Abstract
- New water soluble complex [Zn(HPDDA)2(H2O)2(4,4'-Bipy)2] n (I), where H2PDDA is pyridazine- 4,5-dicarboxylic acid, 4,4'-Bipy = 4,4'-bipyridine), has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis (CIF file CCDC no. 835525 ) and elemental analysis. In I, each Zn2+ ion is six-coordinated by two oxygen atoms from the two HPDDA ligands, two nitrogen atoms from two 4,4'-Bipy and two oxygen atoms from two water molecules. The interactions of I with calf thymus DNA were studied by circular dichroism spectroscopy. The results indicated that this water soluble zinc complex show moderate binding with DNA and could be used for candidate for therapy of cancer.
- Subjects :
- chemistry.chemical_classification
Circular dichroism
010405 organic chemistry
Coordination polymer
General Chemical Engineering
chemistry.chemical_element
General Chemistry
Crystal structure
Zinc
010402 general chemistry
01 natural sciences
0104 chemical sciences
Pyridazine
Bipyridine
chemistry.chemical_compound
Dicarboxylic acid
chemistry
Polymer chemistry
Molecule
Subjects
Details
- ISSN :
- 16083318 and 10703284
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Russian Journal of Coordination Chemistry
- Accession number :
- edsair.doi...........cd8ac609391dc68ca33b11f4a0069d5c