Synthesis, characterization and drug release activity of poly(epichlorohydrin-g-furosemide) system

The poly(epichlorohydrin) (PECH) was synthesized and structurally modified in the presence of furosemide (Fur) under nitrogen atmosphere at 50 °C for 4 h and characterized by various analytical techniques like FTIR, UV–Visible, 1H-NMR, fluorescence emission, SEM, DSC, TGA and GPC. The Fur grafted PECH was subjected to drug release study at three different pHs from which the drug release model and mechanism were determined. The structurally modified PECH exhibited the SO2 stretching at 1121 cm−1. The 1H-NMR spectrum confirmed the chemical grafting of Fur onto PECH backbone. After the chemical grafting reaction, the Mw of PECH was increased to 73,216 g/mol. The drug release under acid pH followed the super case transportation mechanism.