Bond energy enabled amine distinguishing strategy: chemo-, regioselective 1,3-diamination of (trifluoromethyl)alkenes with different amines by two C(sp3)–F bond cleavages

Authors :: Hao Zeng
Hengyuan Li
Chengxi Li
Huanfeng Jiang
Chuanle Zhu
Source :: Organic Chemistry Frontiers. 9:1383-1388
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: ipso-Defluorinative amination-triggered 1,3-diamination of (trifluoromethyl)alkenes with different amines affords various monofluoroalkenylated acyclic 1,3-diamines in high yields with excellent Z/E selectivity.

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