Basic studies on intravascular low-intensity laser therapy

Intravascular low intensity laser therapy (ILILT) was originally put forward in USA in 1982, but popularized in Russia in1980s and in China in 1990s, respectively. A randomized placebo-controlled study has shown ILILT clinical efficacy inpatients suffering from rheumatoid arthritis. As Chinese therapeutic applications ofILILT were the most widely in the world,its basic research, such as intracellular signal transduction research, blood research in vitro, animal blood research in vivo,human blood research in vivo and traditional Chinese medicine research, was also very progressive in China. Its basic studieswill be reviewed in terms ofthe biological information model ofphotobiomodulation in this paper. ILILT might work in viewofits basic studies, but the further randomized placebo-controlled trial and the further safety research should be done..Keywords: photobiomodulation, intravascular low intensity laser therapy, randomized placebo-controlled trial