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The hardwired transcriptional response to DNA damage
- Source :
- Current Opinion in Systems Biology. 19:1-7
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- There is a complex network of interactions between bulky DNA damages and transcription. Bulky damages block RNA polymerases but also elicit a regulated transcriptional response. At the same time, active transcription enhances the ability to recognize and repair damages. Eventually, transcription is completely shut down until after damages are removed. Recent projects untangle this web of interaction in mammalian cells by applying time-sensitive and high-resolution measurements of damage, repair, and transcription at genome-wide scales. The emerging model indicates the transcriptional response to damage is primarily hardwired in the damaged genomic DNA, and transcription shutdown can be explained almost completely by (1) aborted transcription by blocked RNA polymerases and (2) ubiquitination and degradation of RNA polymerase II after encountering a damage.
- Subjects :
- 0303 health sciences
DNA damage
Applied Mathematics
RNA
RNA polymerase II
Biology
General Biochemistry, Genetics and Molecular Biology
Computer Science Applications
Cell biology
03 medical and health sciences
chemistry.chemical_compound
genomic DNA
0302 clinical medicine
chemistry
Ubiquitin
Transcription (biology)
Modeling and Simulation
Drug Discovery
biology.protein
030217 neurology & neurosurgery
DNA
Polymerase
030304 developmental biology
Subjects
Details
- ISSN :
- 24523100
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Systems Biology
- Accession number :
- edsair.doi...........ccfc2676b71470006829e65c043b3050