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The Absorption of Vitamin B12after Subtotal Pancreatectomy in the Rat
- Source :
- Scandinavian Journal of Gastroenterology. 11:683-688
- Publication Year :
- 1976
- Publisher :
- Informa UK Limited, 1976.
-
Abstract
- Subtotal pancreatectomy in the rat was performed by a new method. Except for a small remnant along the splenal hilus, the gland was completely removed. Exocrine pancreatic insufficiency was confirmed by fat and nitrogen malabsorption. A moderate diabetes mellitus was seen. Insulin substitution or diet restriction was unnecessary. The absorption of vitamin B12 after oral administration of 10 ng 57CoB12 was 5.0 +/- 0.2 (ng 57CoB12 +/- S.E.M.) in unoperated rats and 5.1 +/- 0.1 in pancreatectomized rats (p greater than 0.5). Pancreatic extract (PE) (100 mg) increased the absorption of 57CoB12 in unoperated rats (p less than 0.01), but not in pancreatectomized rats (p greater than 0.2). PE (300 mg) reduced the absorption in unoperated rats (p less than 0.01). The results indicate that an optimal amount of pancreatic secretion may stimulate the absorption of vitamin B12.
- Subjects :
- medicine.medical_specialty
Malabsorption
Chemistry
Insulin
medicine.medical_treatment
General surgery
Gastroenterology
Absorption (skin)
medicine.disease
Endocrinology
Oral administration
Internal medicine
Diabetes mellitus
medicine
Vitamin B12
Exocrine pancreatic insufficiency
Subtotal pancreatectomy
Subjects
Details
- ISSN :
- 15027708 and 00365521
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi...........ccaad6f1778ee4001dc5381503e74e0e