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Abstract TMP19: Intravenous Recombinant Tissue-type Plasminogen Activator Use in Young Adults With Acute Ischemic Stroke
Abstract TMP19: Intravenous Recombinant Tissue-type Plasminogen Activator Use in Young Adults With Acute Ischemic Stroke
- Source :
- Stroke. 48
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Background: Intravenous recombinant tissue-type plasminogen activator (rt-PA) administration improves outcomes in acute ischemic stroke. However, young patients ( Methods: We analyzed data from the large national Get With The Guidelines–Stroke registry for acute ischemic stroke patients hospitalized between January 2009 and September 2015. Multivariable models with generalized estimating equations (GEE) were used to test for differences between younger (age 18-40) and older (age > 40) acute ischemic stroke patients, controlling for patient and hospital characteristics including stroke severity. Results: Of 1,320,965 AIS patients admitted to participating hospitals, 2.3% (30,448) were aged 18-40. Among these patients, 12.5% received rt-PA versus 8.8% of those aged >40 (p Conclusions: Young acute ischemic stroke patients did not receive rt-PA treatment at lower rates than older patients. Outcomes were better and the rate of symptomatic intracranial hemorrhage was lower in the young patients. However, younger patients had significantly longer door-to-CT and DTN times, providing an opportunity to improve the care of these patients.
- Subjects :
- Advanced and Specialized Nursing
medicine.medical_specialty
business.industry
medicine.medical_treatment
Thrombolysis
medicine.disease
law.invention
law
Internal medicine
Ischemic stroke
medicine
Recombinant DNA
Tissue type
Neurology (clinical)
Young adult
Cardiology and Cardiovascular Medicine
Intensive care medicine
business
Plasminogen activator
Stroke
Acute ischemic stroke
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi...........cc5e8f2049e06d2d5d0792e591ecb200
- Full Text :
- https://doi.org/10.1161/str.48.suppl_1.tmp19