Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction

Authors :: Kevin M. Maloney
Aaron M. Whittaker
David J. Waterhouse
Neil A. Strotman
Mark A. Huffman
Sumei Ren
Christopher C. Nawrat
Hao Yang
Source :: Organic Process Research & Development. 25:516-521
Publication Year :: 2020
Publisher :: American Chemical Society (ACS), 2020.
Abstract: We report the synthesis of the carbon-14-labeled unnatural nucleoside islatravir, an investigational HIV drug, through a one-pot biocatalytic cascade starting from acetaldehyde-2-14C. Combining enz...

Subjects :: 010405 organic chemistry
Chemistry
Anti hiv
Organic Chemistry
Human immunodeficiency virus (HIV)
010402 general chemistry
medicine.disease_cause
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Cascade reaction
Biocatalysis
medicine
Physical and Theoretical Chemistry
Nucleoside

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