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New approach for induction of alkyl moiety to aliphatic amines by NaBH(OAc)3 with carboxylic acid
- Source :
- Tetrahedron Letters. 61:151919
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- We had found the novel N-alkylation method, which utilizes carboxylic acids as alkyl sources with sodium triacetoxyborohydride [NaBH(OAc)3]. Our methodology had been revealed to have some advantages over the reported similar procedures. Through the further investigation about our method, it was disclosed that acetonitrile was the suitable solvent and N-alkylation for aliphatic amines were also smoothly proceeded. On the way of the research, we discovered that 4-hydroxybutyl moiety was induced to aniline by use of old THF containing peroxidic materials.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Chemistry
Carboxylic acid
Organic Chemistry
010402 general chemistry
01 natural sciences
Biochemistry
0104 chemical sciences
Solvent
Sodium triacetoxyborohydride
chemistry.chemical_compound
Aniline
Drug Discovery
Organic chemistry
Moiety
Acetonitrile
Alkyl
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........cc0123c6338fcd2fe227a898d12ccb95