Back to Search
Start Over
Diurnal variation in the biliary excretion of flomoxef in patients with percutaneous transhepatic biliary drainage
- Source :
- British Journal of Clinical Pharmacology. 52:65-68
- Publication Year :
- 2001
- Publisher :
- Wiley, 2001.
-
Abstract
- Aims To examine diurnal variation in biliary excretion of flomoxef. Methods Flomoxef (1 g) was injected intravenously in eight patients with percutaneous transhepatic cholangiography with drainage at 09.00 h and 21.00 h by a cross-over design with a 36 h washout period. Drained biliary fluid was collected for 6 h after each dosing. These patients still had mild to moderate hepatic dysfunction. Results Bile flow and bile acid excretion for 6 h after dosing did not differ significantly between the 09.00 h and 21.00 h treatments. The maximum concentration of biliary flomoxef was significantly greater and its total excretion for 6 h tended to be greater after the 21.00 h dose [maximum concentration (µg ml−1): 34.2 ± 29.9 (09.00 h dose) vs 43.5 ± 28.3 (21.00 h dose) (95% confidence interval for difference: 2.6∼15.9, P = 0.013); total excretion (mg 6 h−1): 1.4 ± 1.3 (09.00 h dose) vs 1.6 ± 1.2 (21.00 h dose) (95% confidence interval for difference: −26.8, 313.7, P = 0.087)]. The period that biliary flomoxef remained above the minimal inhibitory concentration did not differ significantly between the two treatment times. Conclusions These results suggest that biliary excretion of flomoxef shows diurnal variation. However, as the difference was relatively small, flomoxef could be given at any time of day without any dosage adjustments.
- Subjects :
- Pharmacology
medicine.medical_specialty
business.industry
medicine.medical_treatment
medicine.disease
Percutaneous transhepatic cholangiography
Crossover study
Gastroenterology
Excretion
Cholestasis
Pharmacokinetics
Biliary tract
Internal medicine
medicine
Pharmacology (medical)
Flomoxef
business
medicine.drug
Antibacterial agent
Subjects
Details
- ISSN :
- 03065251
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology
- Accession number :
- edsair.doi...........cbb6bf5216b2671b973cc0d4d0b78872