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Selectivity in an asymmetric nitrogen insertion process

Authors :
Jeffrey Aubé
Paul M. Burgett
Yuguang Wang
Source :
Tetrahedron Letters. 29:151-154
Publication Year :
1988
Publisher :
Elsevier BV, 1988.

Abstract

A simple and efficient synthesis of chiral lactams utilizing a group-selective nitrogen insertion process has been investigated for a group of prochiral ketones. The preparation of a useful intermediate in benzomorphinan synthesis has been carried out in optically active form.

Subjects

Subjects :
chemistry.chemical_classification
Ketone
Organic Chemistry
chemistry.chemical_element
Optically active
Biochemistry
Nitrogen
chemistry.chemical_compound
chemistry
Scientific method
Drug Discovery
polycyclic compounds
Lactam
Organic chemistry
Selectivity

Details

ISSN :
00404039
Volume :
29
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........cb8c19d742f613adba67ac719798e6f1
Full Text :
https://doi.org/10.1016/s0040-4039(00)80039-8
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