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Mannich-Type Addition Reactions between Lithium Derivatives of Benzo[d]thiazoles andN-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s
- Source :
- European Journal of Organic Chemistry. 2014:2429-2433
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- This study describes the anomalous outcome of the Mannich-type reaction of N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine and Li derivatives of benzo[d]thiazoles, which offers a convenient and generalized method for the synthesis of biologically relevant (E)-1,2-bis(2-benzothiazolyl)ethanes. The mechanism, scope, and scalability of this new reaction are discussed.
Details
- ISSN :
- 1434193X
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- European Journal of Organic Chemistry
- Accession number :
- edsair.doi...........cb6ad0f189d08de435369bd4dd5a5d6f