Back to Search
Start Over
Synthesis and evaluation of Lys 1 (α,γ-Folate)Lys 3 ( 177 Lu-DOTA)-Bombesin(1-14) as a potential theranostic radiopharmaceutical for breast cancer
- Source :
- Applied Radiation and Isotopes. 107:214-219
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The aim of this work was to synthesize Lys(1)(α,γ-Folate)-Lys(3)((177)Lu-DOTA)-Bombesin (1-14) ((177)Lu-Folate-BN), as well as to assess its potential for molecular imaging and targeted radiotherapy of breast tumors expressing folate receptors (FR) and gastrin-releasing peptide receptors (GRPR). Radiation absorbed doses of (177)Lu-Folate-BN (74 MBq, i.v.) estimated in athymic mice with T47D-induced breast tumors (positive to FR and GRPR), showed tumor doses of 23.9±2.1 Gy. T47D-tumors were clearly visible (Micro-SPECT/CT images). (177)Lu-Folate-BN demonstrated properties suitable as a theranostic radiopharmaceutical.
- Subjects :
- chemistry.chemical_classification
Oligopeptide
Radiation
Theranostic Nanomedicine
business.industry
Bombesin
Peptide
medicine.disease
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Breast cancer
chemistry
030220 oncology & carcinogenesis
Cancer research
medicine
DOTA
Molecular imaging
Receptor
Nuclear medicine
business
Subjects
Details
- ISSN :
- 09698043
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- Applied Radiation and Isotopes
- Accession number :
- edsair.doi...........cb25d467eb864ffbca17c359b77f38dd