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Gallic acid protects against Aflatoxin B1‐induced oxidative and inflammatory stress damage in rats kidneys and liver
- Source :
- Journal of Food Biochemistry. 44
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- The adverse effect of Aflatoxin B1 (AFB1 ) exposure in both humans and rodents has been widely reported. The beneficial health effects of gallic acid (GA) against AFB1 -induced toxicity in vitro have been published. Here, we present in vivo findings on AFB1 and GA on hepatorenal function in rats, exposed to AFB1 (75 µg/kg body weight) only or co-treated with GA (20 or 40 mg/kg) for 28 successive days. AFB1 significantly increased pro-inflammatory biomarkers and suppressed IL-10 levels in rats' liver and kidney. AFB1 caused increased (p < .05) oxidative stress by decreasing antioxidant enzymes levels and increasing levels of reactive oxygen and nitrogen species. Furthermore, reduction (p < .05) in cellular glutathione (GSH) levels and increased (p < .05) hepatorenal markers of toxicity were detected in rats treated with AFB1 . These observed alterations were, however, reversed in GA co-treated rats. GA ameliorated AFB1 -induced hepatorenal dysfunction by decreasing oxidative stress and inflammation in rats. PRACTICAL APPLICATIONS: GA can chemoprotect against the damaging effects of toxins contaminating food. GA is widely distributed in plants and in use in industries as antioxidant, immune-regulator, and natural defense agent against infections when consumed. Here, we disclosed that GA ameliorates AFB1 -induced hepatorenal dysfunction by suppressing oxidative stress, inflammation, and enhanced apoptosis, thus improving hepatorenal functions in rats exposed to AFB1.
- Subjects :
- Pharmacology
0303 health sciences
Antioxidant
030309 nutrition & dietetics
medicine.medical_treatment
Biophysics
Inflammation
04 agricultural and veterinary sciences
Cell Biology
Oxidative phosphorylation
Glutathione
medicine.disease_cause
040401 food science
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
chemistry
In vivo
Toxicity
medicine
Gallic acid
medicine.symptom
Oxidative stress
Food Science
Subjects
Details
- ISSN :
- 17454514 and 01458884
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi...........cb16f0c53595f190b0f40c6b0ad63ff9