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ChemInform Abstract: RESEARCH ON DURENE DERIVATIVES. NOTE I. HYPERTENSIVE ACTIVITY OF 2-(2,3,5,6-TETRAMETHYLBENZYL)IMIDAZOLINE AND RELATED COMPOUNDS
- Source :
- Chemischer Informationsdienst. 11
- Publication Year :
- 1980
- Publisher :
- Wiley, 1980.
-
Abstract
- A series of substituted 2-(2,3,5,6-tetramethylbenzyl)imidazolines and related compounds have been synthesized to study the steric and hydrophobic effects on the vasoactivity of the introduction of four methyl groups on the phenyl moiety. The 2-(2,3,5,6-tetramethylbenzyl)imidazoline (I) showed a high hypertensive activity, whereas the 2-benzylimidazoline possesses an adrenolytic activity. The 2-(2,3,5,6-tetramethylphenoxy)methylimidazoline (XVII) retained the hypertensive activity, whereas the corresponding thioether (XIX) was inactive. Some structure-activity relationships with regard to the presence of substituents in the 4-position of the phenyl moiety and on the benzylic CH2 are reported.
Details
- ISSN :
- 00092975
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Chemischer Informationsdienst
- Accession number :
- edsair.doi...........cb1569b3b2e455d8527c478372ff0350