A cascade radical-mediated macrocyclisation–transannulation approach to oestrogen steroids

Authors :: Gerald Pattenden
Miguel Angel González Cardente
Stuart McCulloch
Source :: Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry. 4:571-574
Publication Year :: 2001
Publisher :: Elsevier BV, 2001.
Abstract: A new approach to ring A aromatic steroids, based on cascade 13- endo - trig/dig macrocyclisations followed by sequential 5- exo-trig and 6- exo-trig transannulations, exemplified in the syntheses of the cis,anti,trans tetracycle 9 and the trans,syn tetracycle 13 from the ortho -substituted aryl polyen(yne) precursors, 8 and 12 respectively, is described.

Subjects :: Annulation
Reaction mechanism
Stereochemistry
Aryl
medicine.medical_treatment
Free-radical reaction
General Chemistry
Ring (chemistry)
Steroid
chemistry.chemical_compound
chemistry
Dig
medicine
Stereoselectivity

ISSN :: 13871609
Volume :: 4
Database :: OpenAIRE
Journal :: Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry
Accession number :: edsair.doi...........cacfe03e20b27f4144036b53fbb6463c
Full Text :: https://doi.org/10.1016/s1387-1609(01)01271-3

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