Back to Search
Start Over
Palladium-catalyzed asymmetric allylic alkylation of acyclic ketones for synthesis of 2,2-disubsituted pyrrolidine derivatives
- Source :
- Tetrahedron Letters. 58:1399-1402
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Palladium-catalyzed asymmetric allylic alkylation of acyclic ketones represents a significant challenge in organic synthesis. We report herein that the synthesis of chiral 2,2-disubsituted pyrrolidines from acyclic ketones has been accomplished by using catalytic asymmetric method in the presence of Pd(dba)2 and (R)-binap ligand. Theses reactions occur between allyl methyl carbonate and unstabilized acyclic lithium enolates to provide the products in moderate to good enantioselectivity (up to 81% ee).
- Subjects :
- 010405 organic chemistry
Chemistry
Ligand
Organic Chemistry
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Biochemistry
Pyrrolidine
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Tsuji–Trost reaction
Drug Discovery
Organic chemistry
Lithium
Organic synthesis
Methyl carbonate
Palladium
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........cacddaa4928ae7358481e6b54deafbf2