Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Authors :: Smith, Albert Vernon
Cassano, Patricia A
Zhao, Jing Hua
Eiriksdottir, Gudny
Gislason, Gauti Kjartan
Huffman, Jennifer E
Manichaikul, Ani
Garcia, Melissa
Obeidat, Ma'en
Jackson, Catherine M
Franceschini, Nora
Gieger, Christian
Grkovic, Ivica
Lopez, Lorna M
Wain, Louise V
Albrecht, Eva
Gharib, Sina A
Loth, Daan W
Hancock, Dana B
Aldrich, Melinda C
Hammond, Christopher J
Evans, David M
Zhai, Guangju
Cadby, Gemma
Aspelund, Thor
Artigas, María Soler
Fornage, Myriam
Barroso, Inês
Johnson, Toby
Tang, Wenbo
Campbell, Harry
Couper, David J
Publication Year :: 2011
Publisher :: The University of North Carolina at Chapel Hill University Libraries, 2011.
Abstract: Pulmonary function measures reflect respiratory health and predict mortality, and are used in the diagnosis of chronic obstructive pulmonary disease (COPD). We tested genome-wide association with the forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in 48,201 individuals of European ancestry, with follow-up of top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P

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